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Add：C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
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- Usage Introduction
- Product advantages
- Commodity name: ICOS
- Commodity ID: 1080800698003247104
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
Person ICOS (Inducible Costimulator)
Inducible costimulatory molecule ICOS (Inducible costimulator), also known as AILIM (activiation-inducible lymphocyte immune mediatory molecule), or CRP-1 (CD28-related protein-1), is a member of the CD28 family. ICOS is a homodimer composed of 2 subunits, belongs to type I transmembrane protein, and belongs to the immunoglobulin superfamily. ICOS consists of 199aa, containing a signal peptide of 20aa, an extracellular region of 121aa, a transmembrane region of 23aa, and a cytoplasmic region of 35aa. Its cytoplasmic region contains the YMFM motif and can bind to PI3K kinase; the extracellular region contains a V-like Ig functional region, in which the FDPPF motif is a structure that binds to the corresponding ligand ICOSL. The gene product of COSL is a transmembrane glycoprotein composed of 309 amino acids, about 63-72 kD. The extracellular region is similar to other molecules of the B7 family, including IgV and IgC regions. The intracellular segment of the molecule depends on different physiological environments and The cell itself splices to form different isomers. Among them, 4 cysteine and 80 tyrosine in the IgV region are conserved sites, which are not only the signature sites of the B7 family, but also very important for the formation of immunoglobulin-like structures.
ICOS and its ligand ICOSL, combined with the co-stimulatory signal mediated, can regulate T cell activation, proliferation and cytokine secretion. Recent studies have confirmed that the ICOS / ICOSL signaling pathway is associated with inflammatory reactions, autoimmune diseases, tumors, and transplant rejection.
The ICOS-his and ICOS-Fc expressed by the mammalian cells of the company have high purity and good activity.
Expression host: HEK293
Molecular weight: 45-52Kd
Concentration: 1-2mg / ml
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment