CD40 Fc tag

CD40, also known as TNFRSF5, belongs to the tumor necrosis factor receptor superfamily (TNFR-SF) and is a type I transmembrane glycoprotein with a molecular weight of 45-50 kD. There are 173 extracellular, transmembrane and 62 cytoplasmic regions of AA at amino terminal. Like other members of the TNFR family, the extracellular segment of CD40 contains four serine-rich amino acid repeats (CRDs1-CRDs4), which bind to CD40L mainly in CRD2 and CRD3. CD40 is mainly expressed in B cells, thymic epithelial cells, activated monocytes/macrophages, dendritic cells, hematopoietic cells, epithelial cells, endothelial cells and some tumors (such as ovarian cancer, nasopharyngeal cancer, bladder cancer, liver cancer, adenocarcinoma, Hodgkin's disease, chronic lymphocytic leukemia, non-Hodgkin's B lymphoma, multiple myeloma, non-small cell lung cancer). In thymus, CD40 is expressed in cortex, medulla and thymic stromal cells. When stimulated by inflammatory cytokines such as IL-1, IL-3, TNF-alpha, GM-CSF and IFN-gamma, the ability of these cells to express CD40 was significantly enhanced. When stimulated by IFN-gamma, the expression of CD40 was up-regulated most significantly and could stimulate the expression of CD40 in tumor cells.

CD40 (Fc tag)

Cat#Abt-P-408b

Expression host: HEK293

Molecular weight: 55-60 kD

Concentration: 1-2 mg/ml

Purity: > 90%

Preservation environment: 1 x PBS (pH 7.4)