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- Description
- Usage Introduction
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Diagnostic indicators for renal injury can be used to prepare antibodies or for the preparation of calibration and quality control substances
Cystatin C (Cys C)
Cystatin C (Cystatin C, Cys C)
Cys C is a cysteine protease inhibitor, also known as γ-trace protein and γ-post globulin, widely present in nucleated cells and body fluids of various tissues, is a low molecular weight, alkaline Non-glycated protein, with a molecular weight of 13.3KD, is composed of 122 amino acid residues and can be produced by all nucleated cells in the body, with a constant production rate. Cystatin C in the circulation is only cleared by glomerular filtration. It is an endogenous marker that reflects changes in glomerular filtration rate and is reabsorbed in the proximal tubule, but it is completely reabsorbed after reabsorption It is metabolized and does not return to the blood. Therefore, its blood concentration is determined by glomerular filtration and does not depend on any external factors, such as gender, age, and diet. It is an ideal to reflect changes in glomerular filtration rate. Homology markers.
Normally, the concentration of Cys C in serum and plasma is 0.51-1.09mg / L (reference range). When renal function is impaired, the concentration of Cys C in the blood changes with the change of glomerular filtration rate. When renal failure occurs, the glomerular filtration rate decreases, and the concentration of Cys C in the blood can increase more than 10 times if The glomerular filtration rate is normal, and when the renal tubules malfunction, it will prevent Cys C from being absorbed and rapidly decomposed in the renal tubules, increasing the urine concentration by more than 100 times.
Product manual:
Dosage form: clear liquid or dry powder
Storage buffer: PBS buffer, pH7.4
Basic Information:
Source: Gene recombinant expression
Molecular weight: about 13kDa (SDS-PAGE detection)
Purity:
Storage conditions: storage at 4 ℃, or long-term storage at -20 ℃ or -80 ℃ aftersub-packaging
Transportation conditions: Low temperature ice pack
Safety Tips: Not for human experiment
Key words:- Fluorescent molecular
- Substrates
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Fax：0711-3704 589
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