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- Description
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Diagnostic indicators for left ventricular dysfunction and heart failure, which can be used for preparing antibodies or preparing calibration and quality control substances
N-terminal pro-brain natriuretic peptide (NT-proBNP)
The form of brain natriuretic peptide in cardiomyocytes is brain natriuretic peptide precursor (also known as pro-brain natriuretic peptide, ProBNP), brain natriuretic peptide (BNP), N-terminal brain natriuretic peptide precursor (also known as amino terminal pro-brain natriuretic peptide, NT -ProBNP) Three types.
BNP is a polypeptide composed of 32 amino acids, containing a circular structure composed of 17 amino acids, and is a short peptide hormone secreted by the heart. The 134 amino acid Pre-pro-BNP synthesized in cardiomyocytes degrades into the BNP precursor (proBNP) containing 108 amino acids after entering the blood circulation, and proBNP forms a biologically active BNP and a Inactive 76 amino acid fragment NT-proBNP.
BNP is a biologically active protein with a half-life of 20 minutes, its in vitro stabilization time is only 1 hour, and its level is susceptible to the selected drugs, such as patients receiving recombinant human brain BNP (rh-BNP) for treatment Causes elevated levels of BNP in the blood. For the increase in BNP levels, it is difficult for clinicians to determine whether it is caused by drug therapy or cardiac dysfunction.
As an inactive NT-proBNP, the half-life is 60-120 minutes, the in vitro stabilization time is up to 24 hours, it has higher sensitivity, and is not affected by rh-BNP, which is convenient for clinicians to accurately detect early and mild heart failure.
Human NT-proBNP Human NT-proBNP
Expression host: E.coli Expression host: HEK293
Molecular weight: 13kD Molecular weight: 17-27kD
Concentration: 1-2mg/ml Concentration: 1-2mg/ml
Purity:> 90% Purity:> 90%
Storage environment: 1×PBS (pH7.4) Storage environment: 1×PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment
E. coli expresses NT-proBNP mammalian cells 293 express NT-proBNP
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