Human epididymis protein 4 (HE4)

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Add:C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province


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  • Description
  • Usage Introduction
  • Product advantages
    • Commodity name: Human epididymis protein 4 (HE4)
    • Commodity ID: 1080800576867553280
    • 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃

    Ovarian cancer diagnosis can be used for preparing antibodies or preparing calibration and quality control substances

    Human epididymis protein 4 (Human epididymis protein 4, HE4)

    Ovarian cancer is a common malignant tumor that occurs in ovarian tissue, and its incidence rate ranks third among the three major gynecological malignant tumors. It is not easy to be found because of its early symptoms are not obvious. The annual survival rate drops from 70-90% to 20%, so early diagnosis is crucial to the cure rate of ovarian cancer.

    Human epididymis protein 4 (HE4) is a tumor cell surface antigen in female ovarian cancer. Although cancer antigen 125 (CA125) is widely used in the clinical diagnosis of ovarian cancer detection, studies have shown that HE4 is superior to CA125 in the early diagnosis of ovarian cancer, especially for patients with benign ovarian cancer, HE4 is currently ovarian cancer The most sensitive tumor marker for diagnosis.     

    HE4 is found in the epididymis of human epididymis. It is a product of the selective cleavage of the WFDC2 gene, has a highly conserved WAP domain, and is a core region of 4 disulfide bonds composed of 8 cysteines. The HE4 provided by our company is a gene recombinant product expressed by mammalian cells. The expression product has high purity, and the immunogenicity and biological activity are very good. The antibody prepared with this protein can be used as the core material of the early diagnosis kit for ovarian cancer, and the protein itself can also be used as a calibrator.

    General Information:

    Expression host: HEK293

    Molecular weight: 23-27Kd

    Concentration: 1-2mg / ml

    Purity:> 90%

    Storage environment: 1 × PBS (pH7.4) Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing

    Safety Tips: Not for human experiment

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