Kit materials and others
Add：C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
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- Usage Introduction
- Product advantages
- Commodity name: Dickkopf-1（DKK1）
- Commodity ID: 1080800579556102144
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
DKK-1 (Dickkopf-1, DKK-1)
Dickkopf-1 (DKK-1), a secreted glycoprotein, is a member of the DKKs (Dickkopfs) family with a molecular weight of about 29 kDa, and its expression is regulated by genes such as p53, MYCN, and β-catenin.
DKK-1 plays a negative regulatory role in the Wnt pathway by binding to cell surface receptors LRP5/6 and Kremen1/2, and its ectopic expression in cells can inhibit the proliferation of a variety of tumor cells. But sometimes it can induce apoptosis in the presence of pro-apoptotic factors, thus determining the differentiation, proliferation, migration or carcinogenesis characteristics of cells. The expression and function in the occurrence, development and metastasis of different tumors show complex and multiple differences.The study confirmed that DKK-1 significantly inhibited the growth and maturation of Hela cells in cervical cancer.
The DKK-1 provided by our company is a gene recombinant product expressed by mammalian cells, with high purity, excellent immunogenicity and biological activity.The protein can be used to prepare the corresponding DKK-1 antibody, and can also be used as a calibrator itself. It can be used in the development and production of the Wnt pathway inhibitor DKK-1 detection kit.In addition, the study of DKK-1 for targeted therapy of cancer (especially cervical cancer) is of great significance.
Dosage form: white lyophilized powder (or colorless liquid)
Protein concentration: about 1-3 mg/ml
Source: Gene recombination expression
Molecular weight: about 40-46 kDa (SDS-PAGE detection)
Purity:≥95% (SDS-PAGE detection)
Storage conditions: freeze-dried powder stored at 4 C or long-term storage at -20 C, try to avoid repeated freeze-thaw
Transportation conditions: ice bags with low temperature
Safety Tips: It is strictly forbidden to usefor human experiments