Fibroblast activating protein (FAP)

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Add:C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province


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  • Description
  • Usage Introduction
  • Product advantages
    • Commodity name: Fibroblast activating protein (FAP)
    • Commodity ID: 1080800582160764928
    • 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃

    Fibroblast growth, control of epithelial mesenchymal interactions, tissue repair, and epithelial carcinogenesis

    Fibroblast Activating Protein (FAP) (Fibroblast Activating Protein α, FAP α)

    Fibroblast activating protein alpha, also known as Seprase protein or melanoma membrane-bound gelatinase, is a 170 kDa protein encoded by the FAP gene (2q23) in humans and is a homodimer, a membrane gelatinase belonging to the serine protease family.It is selectively expressed in the reactive matrix of epithelial cancer fibroblasts, granulation tissue of healed wounds, and malignant cells of bone and soft tissue sarcomas.This protein is thought to be associated with fibroblast growth during development, control of epithelial-mesenchymal interactions, tissue repair, and epithelial carcinogenesis.

    FAP, also known as seprase, belongs to the SC protease family and is a subfamily of S9B proline oligopeptidases.Other members of the S9B subfamily include DPPIV, DPP8, and DPP9. FAP has a high correlation with DPPIV, they have about 50% of the same amino acids. FAP is a 170 kDa dimer with catalytic activity, and has both dipeptidase and gelatinase activities.The presence of glycine is required for gelatinase activity at the P2 position.

    The FAP provided by our company is a gene recombinant product expressed by mammalian cells with high purity, excellent immunogenicity and biological activity.

    General information:

    Expression host: HEK293 mammalian cells

    Source: A DNA sequence encoding the extracellular region of human FAP (NP_004451.2)

    Preservation buffer: PBS (pH 7.4)

    Molecular weight: about 85-95 KDa (SDS-PAGE detection)

    Purity: ≥90% (SDS-PAGE test)

    Storage conditions: short-term storage at 4 C or long-term storage at -20 C, avoid repeated freeze-thaw as much as possible

    Transportation conditions: ice bags with low temperature

    Safety Tips: Not for Human Experiments

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