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Add：C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
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- Usage Introduction
- Product advantages
- Commodity name: ErbB1（EGFR） his tag
- Commodity ID: 1080800603472023552
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
Human EGFR (ErbB1)
EGFR belongs to the family of epidermal growth factor receptors. EGFR is a type I transmembrane glycoprotein that can bind a series of family ligands, including EGF (epidermal growth factor), amphiregulin (amphmodulin), and TGF-α (transforming growth Factor-α subunit), betacellulin (cytomodulin), etc. EGFR plays an important role in regulating cell proliferation, survival, and differentiation. EGFR binds to ligands to induce homo- or heterodimerization. After dimerization, tyrosine autophosphorylation and downstream pathways are activated: mitogen-activated protein (MAPK), phosphatidylinositol kinase -3 (PI3K) -Akt (PI3K / PKB) and signal transduction and transcription factor 3 (STAT). In addition, EGFR signaling also has an effect on canceration and disease progression, so EGFR is currently used as a target for cancer treatment.
The EGFR mammalian cells produced by our company are recombinantly expressed, with high purity, high immunogenicity and high biological activity, and have a high affinity for the therapeutic antibody Erbitux.
Expression host: HEK293 mammalian cells
Source: A DNA sequence encoding the extracellular domain of human EGFR (NM_005228.3)
Storage buffer: PBS (pH7.4)
Molecular weight: about 95-115KDa (SDS-PAGE detection)
Purity: ≥95% (SDS-PAGE detection)
Storage conditions: Short-term storage at 4℃ or long-term storage at -20℃, try to avoid repeated freezing and thawing.
Transportation conditions: Low temperature ice pack
Safety Tips: Not for human experiment