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Add：C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
E-mail：18062302654@163.com
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- Description
- Usage Introduction
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Inhibiting cellular and humoral immune responses is expected to become a new immunosuppressive drug
Human CTLA-4 (cytotoxic T lymphocyte-associated antigen-4)
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), also known as CD152, a leukocyte differentiation antigen, is a transmembrane receptor on T cells. CTLA-4 is composed of a signal peptide of 35aa, an extracellular region of 126aa, a transmembrane region of 21aa, and a cytoplasmic region of 41aa. CTLA-4 and CD28 share B7 molecular ligands, and CTLA-4 and B7 molecules combine to induce T cell anergy and participate in the negative regulation of immune response. The recombinant CTLA-4 Ig can effectively and specifically inhibit cellular and humoral immune responses in vivo and in vivo, and has a significant therapeutic effect on transplant rejection and various autoimmune diseases. It has extremely low toxic and side effects and is currently considered to be New immunosuppressive drugs desired.
CTLA4-his and CTLA-Fc expressed by the mammalian cells of the company have high purity and good activity.
CTLA4 (Fc tag)
Expression host: HEK293
Molecular weight: 50-55 kD
Concentration: 1-2mg / ml
Purity:> 90%
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment
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Address: C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
Fax：0711-3704 589
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