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- Usage Introduction
- Product advantages
- Commodity name: CTLA-4 Fc tag
- Commodity ID: 1080800642978172928
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
Human CTLA-4 (cytotoxic T lymphocyte-associated antigen-4)
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), also known as CD152, a leukocyte differentiation antigen, is a transmembrane receptor on T cells. CTLA-4 is composed of a signal peptide of 35aa, an extracellular region of 126aa, a transmembrane region of 21aa, and a cytoplasmic region of 41aa. CTLA-4 and CD28 share B7 molecular ligands, and CTLA-4 and B7 molecules combine to induce T cell anergy and participate in the negative regulation of immune response. The recombinant CTLA-4 Ig can effectively and specifically inhibit cellular and humoral immune responses in vivo and in vivo, and has a significant therapeutic effect on transplant rejection and various autoimmune diseases. It has extremely low toxic and side effects and is currently considered to be New immunosuppressive drugs desired.
CTLA4-his and CTLA-Fc expressed by the mammalian cells of the company have high purity and good activity.
CTLA4 (Fc tag)
Expression host: HEK293
Molecular weight: 50-55 kD
Concentration: 1-2mg / ml
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment