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- Usage Introduction
- Product advantages
- Commodity name: PD-L1 Fc tag
- Commodity ID: 1080800648283967488
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
(programmeddeath- 1 ligand, B7-H1, CD274)
PD-L1 (programmeddeath-1 ligand), also known as B7-H1, or CD274, is a member of the B7 family of immunomodulatory molecules and is a transmembrane glycoprotein with a molecular weight of approximately 65 kD. Mature human PD-L1 is composed of a 220 amino acid extracellular region (containing 2 immunoglobulin-like regions), a 21 amino acid transmembrane region, and a 31 amino acid cytoplasmic region. The interaction between PD-1 and PD-L1 can inhibit the proliferation of T cells and at the same time inhibit their production of IL-2, INF-γ and IL-10. Recent studies have shown that the use of Anti-PD-L1 mAb in the body can regulate autoimmune diseases. Blocking the interaction between PD-1 and PD-L1 may provide a feasible strategy for future therapeutic regulation of antiviral immunity, antitumor response, and autoimmune diseases.
PD-L1-his and PD-L1-Fc expressed by our company's mammalian cells have high purity and good activity.
Human PD-L1 (Fc tag)
Expression host: HEK293
MMolecular weight: 68-75kd
Concentration: 1-2mg / ml
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment