+
  • 1显色底物CAS77-86-1Tris.png

Classification:

Kit materials and others

Add:C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province

E-mail:18062302654@163.com

Scan

Follow WeChat mini program

Real time understanding of company dynamics

  • Description
  • Usage Introduction
  • Product advantages
    • Commodity name: Tim-3 his tag
    • Commodity ID: 1080800650867658752
    • 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃

    Differentiated and mature Th1 cells can downregulate Th1 type cell immune response by binding to their ligand galactin-9

    Tim-3 (T cell immunoglobulin and mucin domain-3)

    T cell immunoglobulin and mucin domain molecule 3 (T cell immunoglobulin and mucin domain-3, Tim-3), also known as HAVCR2, is a member of the immunomodulatory molecule TIM family and is a type I transmembrane glycoprotein of 60 kD molecular weight . Mature human Tim-3 is composed of 181aa extracellular region, 21aa transmembrane region, and 78aa cytoplasmic region. Tim-3 is one of the important members of the T-cell immunoglobulin molecule family and is a key molecule expressed by activated Th1 cells that regulates CD4 + CD25 + regulatory T (TR) cells. Th1 cells express full-length membrane Tim3 (flTim3) and soluble Tim3 (sTim3) by selective splicing of mRNA. Tim-3 is mainly expressed in differentiated and mature Th1 cells, and its ligand galectin-9 can down-regulate Th1-type cellular immune response.

    Tim3-his and Tim3-Fc expressed by mammalian cells of the company have high purity and good activity.

    Tim3 (His tag)

    Expression host: HEK293

    Molecular weight: 28-52 kD

    Concentration: 1-2mg / ml

    Purity:> 90%

    Storage environment: 1 × PBS (pH7.4

    Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.

    Safety Tips: Not for human experiment

Message Enquiry