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- Usage Introduction
- Product advantages
- Commodity name: Tim-3 Fc tag
- Commodity ID: 1080800653484904448
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
Tim-3 (T cell immunoglobulin and mucin domain-3)
T cell immunoglobulin and mucin domain molecule 3 (T cell immunoglobulin and mucin domain-3, Tim-3), also known as HAVCR2, is a member of the immunomodulatory molecule TIM family and is a type I transmembrane glycoprotein of 60 kD molecular weight . Mature human Tim-3 is composed of 181aa extracellular region, 21aa transmembrane region, and 78aa cytoplasmic region. Tim-3 is one of the important members of the T-cell immunoglobulin molecule family and is a key molecule expressed by activated Th1 cells that regulates CD4 + CD25 + regulatory T (TR) cells. Th1 cells express full-length membrane Tim3 (flTim3) and soluble Tim3 (sTim3) by selective splicing of mRNA. Tim-3 is mainly expressed in differentiated and mature Th1 cells, and its ligand galectin-9 can down-regulate Th1-type cellular immune response.
Tim3-his and Tim3-Fc expressed by mammalian cells of the company have high purity and good activity.
Tim3 (Fc tag)
Expression host: HEK293
Molecular weight: 54-80 kD
Concentration: 1-2mg / ml
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment