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- Usage Introduction
- Product advantages
- Commodity name: CLDN18.2
- Commodity ID: 1080800666428526592
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
Human CLDN18.2 (Claudin 18.2)
Claudin is an integral membrane protein (Integral Membrane Protein) in the tight junction of epithelium and endothelium The claudin 18 (CLDN18) molecule is an integrated transmembrane protein (quaternary transmembrane protein) with four transmembrane hydrophobic regions and two extracellular loops. CLDN18 exists in two different splice variants, CLDN18.1, and CLDN18.2. Splice variants CLDN18.1 and CLDN18.2 differ in the N-terminal portion containing the first transmembrane (TM) region and Loop 1, while the C-terminal protein has the same primary sequence.
CLDN18.1 is selectively expressed in normal lung cells, while CLDN18.2 is only expressed on gastric cells. However, the expression of CLDN18.2 in normal stomach is limited to differentiated gastric epithelial short-lived cells. It has been confirmed that CLDN18.2 is expressed in various tumor tissues. For example, it has been found that CLDN 18.2 is expressed in pancreatic cancer, esophageal cancer, gastric cancer, bronchial cancer, breast cancer, and ENT tumors. CLDN18.2 is a valuable target for the prevention and / or treatment of primary tumors such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer (such as non-small cell lung cancer (NSCLC)), ovarian cancer, colon cancer, Liver cancer, head and neck cancer and gallbladder cancer and their metastatic cancer, especially gastric cancer metastasis such as Krukenberg tumor, peritoneal metastasis and lymph node metastasis.
The differential expression of CLDN18.2 between cancer cells and normal cells, its membrane localization, its absence in most normal tissues related to toxicity, and its expression in the stomach are limited to non-negative cells that can be supplemented by gastric target negative stem cells The necessary cell population-differentiated gastric cells, makes CLDN18. 2 an attractive target for cancer immunotherapy, and the use of antibody-based therapeutics (Therapeutics) targeting CLDN 18.2 in cancer therapy enables high levels of Treatment specificity becomes possible.
Human CLDN18.2 (Fc tag)
Expression host: HEK293
Molecular weight: 36-40Kd
Concentration: 1-2mg / ml
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment