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Add:C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province

E-mail:18062302654@163.com

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  • Description
  • Usage Introduction
  • Product advantages
    • Commodity name: TNFα his tag
    • Commodity ID: 1080800676968812544
    • 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃

    Related protein research

    Human tumor necrosis factor α (human TNFα)

    Tumor necrosis factor (TNF, tumor necrosis factor) is mainly produced by activated macrophages, NK cells and T lymphocytes. In 1985, Shalaby named TNF produced by macrophages as TNF-α, and lymphotoxin (LT) produced by T lymphocytes as TNF-β. Although TNF-α and TNF-β are only about 30% homologous, they share a common receptor. The biological activity of TNFα accounts for 70% to 95% of the total activity of TNF, so TNF is often referred to as TNF-α.

    The precursor of human TNF-α is composed of 233 amino acids (26kDa), which contains a signal peptide composed of 76 amino acid residues. TNF-α (17 kDa). Since there are no methionine residues, there is no glycosylation site, and the two cysteine ​​at positions 69 and 101 form an intramolecular disulfide bond. Human TNF-α and mouse TNF-α have 79% amino acid homology. The biological effect of TNF-α seems to have no obvious species specificity.

    The human TNFα provided by our company has high purity and good activity.

    Human TNFα (His tag) 

    Expression host: HEK293

    Protein serial number: NP_000585.2 (extracellular region)

    Molecular weight: 17 kD 

    Concentration: 1-2mg / ml

    Purity:> 90% 

    Storage environment: 1 × PBS (pH7.4)

    Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.

    Safety Tips: Not for human experiment

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