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Related protein research
Human tumor necrosis factor α (human TNFα)
Tumor necrosis factor (TNF, tumor necrosis factor) is mainly produced by activated macrophages, NK cells and T lymphocytes. In 1985, Shalaby named TNF produced by macrophages as TNF-α, and lymphotoxin (LT) produced by T lymphocytes as TNF-β. Although TNF-α and TNF-β are only about 30% homologous, they share a common receptor. The biological activity of TNFα accounts for 70% to 95% of the total activity of TNF, so TNF is often referred to as TNF-α.
The precursor of human TNF-α is composed of 233 amino acids (26kDa), which contains a signal peptide composed of 76 amino acid residues. TNF-α (17 kDa). Since there are no methionine residues, there is no glycosylation site, and the two cysteine at positions 69 and 101 form an intramolecular disulfide bond. Human TNF-α and mouse TNF-α have 79% amino acid homology. The biological effect of TNF-α seems to have no obvious species specificity.
The human TNFα provided by our company has high purity and good activity.
Human TNFα (His tag)
Expression host: HEK293
Protein serial number: NP_000585.2 (extracellular region)
Molecular weight: 17 kD
Concentration: 1-2mg / ml
Purity:> 90%
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment
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