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Related protein research
Dog tumor necrosis factor (Dog TNF)
Tumor necrosis factor (TNF) is mainly produced by activated macrophages, NK cells and T lymphocytes. In 1985, Shalaby named TNF produced by macrophages as TNF-α, and lymphotoxin (LT) produced by T lymphocytes as TNF-β. Although TNF-α and TNF-β are only about 30% homologous, they share a common receptor. The biological activity of TNFα accounts for 70% to 95% of the total activity of TNF, so TNF is often referred to as TNF-α.
The human TNF-α precursor is composed of 233 amino acids (26kDa), which contains a signal peptide composed of 76 amino acid residues. Under the action of TNF converting enzyme TACE, the signal peptide is excised to form a mature 157 amino acid residue. TNF-α (17 kDa). Since there are no methionine residues, there is no glycosylation site, and the two cysteine at positions 69 and 101 form an intramolecular disulfide bond. Human TNF-α and mouse TNF-α have 79% amino acid homology. The biological effect of TNF-α seems to have no obvious species specificity.
The dog TNFα provided by our company has high purity and good activity. A
Dog TNFα (Fc tag)
Expression host: HEK293
Molecular weight: 42 kD
Concentration: 1-2mg / ml
Purity:> 90%
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment
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Address: C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
Fax：0711-3704 589
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