Biological Buffer Tromethamine-A Mild and Safe Cosmetic Additive

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Tromethamine, alias Tris, trishydroxymethylaminomethane, CAS77-86-1. It is a white crystal or powder. Tris (trishydroxymethylaminomethane) has a wide range of uses. It can be used as an intermediate for fosfomycin and as a vulcanization accelerator, mineral oil and paraffin emulsifier.

It can also be used as an acid gas absorbent, formulating buffers, surfactants, emulsifiers and accelerators. For a magical purpose, tromethamine is also a mild and safe cosmetic additive.

TRIS (Trishydroxymethylaminomethane) structure diagram


As a cosmetic additive, tromethamine is commonly used in some up-market cosmetics, covering Japan, South Korea, Europe and the United States. For example, the "LANEIGE Reservoir Series", "Sulwhasoo" and SKII Fairy Water, which are known as "supplements of water", such as Clarins Gold Double Extract Essence and Clinique Water Magnetic Cream. It is worth mentioning that tromethamine is also used in maternal and infant products, and it is present in the popular multi-effect cream for infants at the beginning.


So what role does tromethamine play in cosmetics?


The pKa of tromethamine at 25℃ is 8.06, and the pH buffer range is 7.0~9.0. The most important role played in cosmetics is to adjust the PH value of the product. Because the skin can only be in the best state to absorb nutrients within the normal pH range (4.5-6.5), the PH value of cosmetics is very important. After adding acid-base regulators such as trometamol, it can make the product close to the PH value of the skin surface, making it more gentle and skin-friendly.


In addition, tromethamine is also commonly used to neutralize thickeners. Mixing with carbomer can reduce the stickiness of emulsions, creams and other products, improve the cellular respiration efficiency of facial skin, and make cellular respiration more smooth and avoid Clogged pores.

Tromethamine is also a dissolution enhancer for salicylic acid, which can prevent the precipitation of salicylic acid and ensure the stability of the product. In addition, in cosmetics containing amine salts, tromethamine also plays a role in odor regulation, so that cosmetics can be adjusted to release a limited amount of amine odor during application, while avoiding any residual or continuous odor release.


Desheng began to develop and produce biological buffers in 2015 and has an independent and mature R&D team. There are also in-depth studies on blood collection tube additives, chemiluminescent reagents, and new Trinder ’s reagents. Carbomer is one of Desheng's hot-sales products. If necessary, it can be matched and purchased, saving time and effort. Looking forward to your further consultation!