Market Status and Mainstream Applications of Tris

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Tris (hydroxymethyl) aminomethane (Tris (hydroxymethyl) aminomethane, commonly referred to as Tris) is a white crystal or powder, known as tromethamine (THAM) in the pharmaceutical industry. It is a chemical substance soluble in ethanol and water, slightly soluble in ethyl acetate and benzene, insoluble in ether and carbon tetrachloride, corrosive to copper and aluminum, and irritating.

Downstream Distribution of Tris-Hydroxymethylaminomethane Industry

At present, the scale of the global tris-hydroxymethylaminomethane market is showing a steady expansion. In 2021, the global market scale will be about 315.37 million US dollars, and the compound annual growth rate (CAGR) from 17 to 21 will be about 18.12%. It is expected to maintain a steady growth trend in the future. , the market size will be close to 1475.89 million US dollars by 2028. According to the market share, Tris mainly includes biological buffers, pharmaceutical intermediates, and other fields. Among them, biological buffer is the core downstream market of Tris, and the sales market size in 2021 will account for about 76.15%.

Mainstream applications of Tris

Biological buffers: Biological buffers are high-end chemical reagent products and are widely used in emerging fields such as biomedicine, in vitro diagnostics and life science research. Tris is usually used as a biological buffer to maintain the pH value of biochemical reactions. Because it is weakly alkaline, it is usually used together with acid. Mainly used for nucleic acid and protein dissolution buffer, Western blotting electrophoresis buffer, Southern blotting experiment buffer, DNA agarose gel electrophoresis buffer, etc.

Pharmaceutical intermediates: Tris(hydroxymethyl)aminomethane has another alias, namely tromethamine, which is an amino-buffered alkali without sodium. It reacts with H2CO3 in body fluids to reduce H2CO3 and at the same time generate HCO32-, It can absorb hydrogen ions to correct acidemia. It has a strong effect and can penetrate the cell membrane. It is often used for acute metabolic and respiratory acidemia, and is used for the correction of acidosis. Because it is used in pharmaceuticals, the entire production raw material source, production process route, product purity and impurity ion content of Tris are strictly required.

Others: Tris can also be used to prepare other compounds such as surfactants and vulcanization accelerators. In the field of coatings, inks and household materials, TRIS can also be used in production processes including coatings, dyes and modified activated carbon. TRIS is also used in personal care and cosmetic products.

At present, Desheng Technology has realized the mass production of TRIS products, with an annual production capacity of about 1,000 tons. In order to better serve customers in various fields, we will continue to optimize the production process of TRIS and improve the quality of products in the later stage. , to provide customers with high-quality, convenient and cost-effective diversified products and services. If you have any ordering needs, welcome to inquire and call!


Biological buffers refer to chemical reagents composed of weak acids and their salts or weak bases and their salts. It is called a buffer solution after being prepared into a solution. When a certain amount of strong acid or strong alkali is added to the solution, it can slow down the pH of the solution. Change the amplitude to keep the pH of the solution roughly stable.