Medical composite material with THAM as raw material

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In recent years, with the development of biological materials, the technical requirements for surface modification of materials have become more and more extensive. Especially when the tissue compatibility, biological activity and antibacterial properties of biological materials need to be improved, biological surface modification technology, especially the preparation of biological coatings, is particularly important.

In the preparation of biological coatings, the earliest technology is deposition coating, cold coating or thermal coating. However, the equipment required is very demanding, and the thermal coating even requires high temperatures. There are some damages on the surface of the coating material. This technology targets a relatively narrow range of materials, mainly metal or ceramic coatings, while the target of the coating material is only metal or ceramic materials. Subsequently, the sol-gel method is used to prepare the coating, but the preparation process is complicated and harmful to the environment.

In-situ surface modification techniques have recently been reported, such as ion implantation, photolithography and other electrochemical processes, but the process is relatively complicated. Therefore, it is necessary to develop a low-cost application technology. The researchers therefore proposed a new type of medical composite material based on tris(hydroxymethyl)aminomethane (THAM), which has the characteristics of good biocompatibility, strong surface adhesion, and uniform coating thickness distribution. , Can be used to modify drugs, such as biopharmaceutical sprays.

Specifically, it includes the following steps:

(1) Mix the base material (barium titanate particles or carbon nanofibers), distilled water, dopamine and TRIS at room temperature (rotating speed 150~200 rpm, stirring for 12~24 hours) for in-situ synthesis. The mass ratio of dopamine to THAM (TRIS) is 1:0.3~0.5:1~3;

(2) Centrifuge the in-situ synthesized solution (rate: 5000 to 10000 rpm, time: 10 to 20 min), wash the lower layer with distilled water, and centrifuge at least twice to dry to obtain the medical composite material.

The coating material used in the method is a biological coating material, which is produced when the organism itself is stimulated or stimulated, and has good biocompatibility. The required raw materials and synthesis process are simple, the cost is low, the thickness of the prepared biological coating is uniform, and it has broad application prospects in the fields of medical sprays and medical bandages. The process is simple and the operation can meet the needs of large-scale production and use. Replace the previously used high-temperature coating technology or complex chemical process.