Advantages of sodium fluoride-dipotassium EDTA combined anticoagulant in blood sugar

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Blood glucose testing is a routine check for people nowadays, which can better control their own blood glucose changes, reduce the risk of diabetes complications, and improve the quality of life of those with diabetes. Therefore, blood glucose test specimens must be selected with appropriate anticoagulants, which can be measured in time, reduce errors, improve accuracy, and provide accurate diagnosis basis for the clinic.


For a long time, sodium fluoride-potassium oxalate anticoagulant is generally used for blood glucose test specimens, but its application is limited due to the complicated production. But after using sodium fluoride-EDTA dipotassium combined anticoagulant as an anticoagulant for blood glucose test specimens, unexpected effects appeared.


Sodium fluoride

It is a weak anticoagulant, its melting point is greater than 990℃, and it can be dried at 100℃ when preparing anticoagulant tube. It can effectively inhibit the enolase in the glycolysis process, so that the dehydration of monophosphoglycerate produced in the third stage of the glycolysis pathway is blocked, resulting in the inability to redistribute the internal energy of the molecule, and ultimately the formation of high-energy phosphoenols. Pyruvate can effectively inhibit glycolysis and keep the blood glucose concentration relatively stable, so it is considered to be an excellent preservative for blood glucose test specimens.

Dipotassium EDTA

It can integrate with the calcium ions in the blood to prevent blood clotting, and has a fast dissolution rate and good anticoagulation effect. In the process of preparing the anticoagulation tube, it can be dried with sodium fluoride at a temperature of 100°C and still maintain the anticoagulation effect without worrying about being decomposed. Therefore, its preparation conditions are easier to control, more convenient to produce, and beneficial to improving efficiency.


Sodium fluoride-EDTA dipotassium combined anticoagulant is used to prepare blood glucose samples, which is more convenient to produce and has better anticoagulant effect. At the same time, it has the inhibitory effect of sodium fluoride on glycolysis and can effectively maintain blood sugar in the specimen. The relative stability of the concentration has great promotion and practical value.