The extraction method and application scope of heparin sodium
The word "liver" in the name of heparin indicates that this substance can be extracted from animal liver, but not only in the liver. Mast cells in many animal tissues can produce and liberate this substance, such as human and animal. Heparin is found in body tissues such as lungs, heart, liver, small intestine and muscles. But because of these many organs, the heparin molecule extracted from the pig small intestine is very close to the molecular structure of humans, and the pig industry in our country is very developed. The supply of pig small intestine is very wide and it is easier to ensure the freshness of the goods, so It is the main extraction source of heparin sodium today.
Since 2009, the export volume of my country's heparin sodium and heparin and other products has steadily increased. Many heparin sodium manufacturers have been in short supply of heparin, which has caused the price of heparin to soar steadily. At the same time, heparin products also successfully entered my country's basic medical insurance catalog in the same year, and they are also a relatively small number of price-raising drugs. This is very good news for the heparin industry and heparin producers. In addition, heparin also has the effects of lowering blood lipids and anti-media smooth muscle cell (SMC) proliferation, and can treat many common symptoms such as frostbite and varicose veins.
Heparin sodium is found in the mast cells in many mammalian tissues and organs. However, due to different national conditions, the main extracts of heparin sodium produced in each place are different. Europe and the United States mainly use cattle’s lungs, while China’s The production line usually selects the mucosa of the pig small intestine. Heparin sodium can be used to prevent and treat thromboembolic diseases, such as: myocardial infarction, pulmonary embolism, cerebrovascular embolism, peripheral venous thrombosis, etc., can prevent the formation and expansion of thrombus, and can also be used in the early stage of DIC, and other anti Condensed. Early application can prevent the depletion of fibrinogen and coagulation factors, and can also replace citrate during blood transfusion or as an extracorporeal anticoagulant during cardiopulmonary bypass.
Heparin sodium is an anticoagulant drug both in vivo and in vitro, as well as a drug that can treat bleeding and coagulation diseases. Therefore, heparin sodium can participate in and interfere with multiple links in the coagulation process, and can play an anticoagulant effect both in vivo and in vitro. Clinically, heparin sodium is most commonly used for anticoagulation and hemodialysis during intravenous infusion. It can also be used to prevent embolic diseases, such as pulmonary embolism, myocardial infarction, deep vein thrombosis and thrombus formed after surgery Wait. It can also treat diffuse intravascular coagulation caused by many reasons, such as placental abruption and sepsis.
It should be noted that although heparin sodium has a wide range of uses, the heparin sodium developed by Desheng is of non-injection grade. It is mainly used as an anticoagulant in blood collection tube additives, that is, an in vitro anticoagulant, which can be used for a certain period of time. To prevent rapid coagulation of blood outside the body after blood collection, major companies must clarify their specific requirements when purchasing.
Trihydroxymethylaminomethane is an important laboratory reagent widely used in fields such as molecular biology and biochemistry. To ensure its quality and purity, a series of tests are required. This article provides measurement methods for appearance, content, solubility, drying weight loss, pH value, melting point, and UV absorbance. These methods help to evaluate the quality and purity of trimethylaminomethane.