Salinization and Enzymatic Hydrolysis of Heparin Sodium: Analysis and Selection of Advantages and Disadvantages

Release time:


Heparin sodium, as a commonly used anticoagulant for blood collection, its source and preparation process have always been of great concern. At present, the production of heparin sodium is mainly obtained through two methods: salt hydrolysis and enzymatic hydrolysis. There are many different opinions on which of these two methods is better. This article will delve into the two processes of salt hydrolysis and enzymatic hydrolysis, analyze their advantages and disadvantages, and provide reference for production practice.

Salt hydrolysis process of heparin sodium

The principle of salt hydrolysis is to use salt to react with the protein in heparin powder to generate heparin salt, and then obtain heparin sodium through ion exchange or dialysis. This method is widely used in the production of heparin sodium, mainly due to its mature technology, relatively simple production process, high production efficiency, and low cost.

1. Mature technology: After years of research and development, the salt hydrolysis process has become quite mature and can stably produce heparin sodium products that meet the requirements. This is due to the widespread application and continuous optimization of this process in industrial production.

2. The production process is relatively simple: compared to the enzymatic hydrolysis process, the salt hydrolysis process is simpler and easier to operate. This helps to reduce production costs and minimize operational issues.

3. High production efficiency: The salt hydrolysis process has a fast reaction speed and can complete large-scale production in a short period of time. This makes the process significantly advantageous in situations where rapid preparation of large amounts of heparin sodium is required.

4. Low cost: The raw material cost of the salt hydrolysis process is relatively low, and the equipment investment is relatively small, so the production cost of the product is low. This helps to improve the economic efficiency and market competitiveness of enterprises.

Enzymatic hydrolysis process of sodium heparin

Enzymatic hydrolysis is the use of specific enzymes to hydrolyze heparin raw powder to obtain sodium heparin. This method is gradually gaining attention in the production of heparin sodium, mainly due to its advantages of high selectivity, mild hydrolysis conditions, and environmental protection.

1. High selectivity: Enzymes have high selectivity and can specifically act on target molecules, resulting in purer and more uniform products. This helps to improve the quality and purity of the product.

2. Mild hydrolysis conditions: The enzymatic hydrolysis process is usually carried out under mild conditions, which can reduce the damage to raw materials and maintain the biological activity of the product. This helps to protect the natural structure and function of heparin sodium.

3. Beneficial for environmental protection: Enzymatic hydrolysis produces less waste and is easy to handle, which is beneficial for reducing environmental pollution. This meets the current requirements for green and sustainable development.

In actual production, selecting the preparation method of heparin sodium requires considering multiple factors. For large-scale, cost sensitive, and low purity requirements for products, salt hydrolysis may be a better choice. However, for some high-end application areas such as pharmaceuticals and biotechnology, enzymatic hydrolysis may be more suitable. These fields require high purity and biological activity of products, and enzymatic hydrolysis has shown significant advantages in these aspects. In addition, for regions or enterprises with strict environmental requirements, choosing enzymatic hydrolysis may be more advantageous because this method generates less waste and has a smaller impact on the environment.

Overall, the salt hydrolysis and enzymatic hydrolysis processes of heparin sodium each have their own advantages and disadvantages. In actual production, appropriate processes should be selected based on specific needs and application scenarios.

Hubei Xindesheng Materials Technology is a professional enterprise that researches and produces blood collection additives. It is also one of the few well-established manufacturers in China that can produce a complete set of blood collection additives. After 18 years of joint efforts by all employees of the company, we have been able to produce affordable and high-quality blood collection additives such as serum separation gel, heparin sodium, heparin lithium, EDTA dipotassium, tripotassium, and disodium, which have also been recognized and praised by our customers. If you are also interested, please click on the official website to learn more!