Stroke is a complex multi-factor and multi-gene disease, which can be caused by the interaction of genes with genes or genes with environment. Hyperhomocysteine (Hhcy) is an important risk factor for ischemic stroke.
Cystathionine beta synthase (CBS) is a homologous tetramer in the cytoplasm. It consists of 63 KD subunits and is a pyridoxal phosphate (PLP) dependent enzyme. Under the catalysis of vitamin B6, CBS can synthesize cysteine from serine and homocysteine (Hcy). As a key enzyme affecting the level of Hcy, CBS plays an important role in the sulfuric acid conversion pathway from Hcy to cystathionine. The enzyme is used for the detection of homocysteine in blood in the method of enzyme circulation.
Formulation: yellowish, yellow powder, or liquid
Preservation buffer before freeze-drying: phosphoric acid buffer, pH 7.4
Source: Microbial recombinant expressed protein
Isoelectric point: 6.49
Enzymology number: EC220.127.116.11
PH stability: 7.4-8.5
Molecular weight: about 56KDa (SDS-PAGE detection)
Purity: > 90% (SDS-PAGE test)
Enzyme activity: 150 U/mg protein
The activity of NADH was defined as a unit of enzyme activity at 37 C and pH 8.0. The absorbance of NADH decreased by 0.01 at 340 nm by catalytic reaction per minute under fixed reaction conditions.
Preservation Conditions: Store at 4 (- 20 or - 80 C) for about one year, and keep for a longer time, avoiding repeated freezing and thawing as far as possible.
Transportation Conditions: Low Temperature Ice Bag
Purpose: The protein can be used in the development and production of cysteine assay kit for detection of Hcy.
Safety Tips: This reagent is only used for research and development or production, and is strictly prohibited for human or animal experiments.
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