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CD40 Fc tag

PRODUCT NUMBER:CP02-DF078 INTRODUCTION:Surface expression of various tissues and cells.
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Product description
PACKAGE
Dispensable
CD40, also known as TNFRSF5, belongs to the tumor necrosis factor receptor superfamily (TNFR-SF) and is a type I transmembrane glycoprotein with a molecular weight of 45-50 kD. There are 173 extracellular, transmembrane and 62 cytoplasmic regions of AA at amino terminal. Like other members of the TNFR family, the extracellular segment of CD40 contains four serine-rich amino acid repeats (CRDs1-CRDs4), which bind to CD40L mainly in CRD2 and CRD3. CD40 is mainly expressed in B cells, thymic epithelial cells, activated monocytes/macrophages, dendritic cells, hematopoietic cells, epithelial cells, endothelial cells and some tumors (such as ovarian cancer, nasopharyngeal cancer, bladder cancer, liver cancer, adenocarcinoma, Hodgkin's disease, chronic lymphocytic leukemia, non-Hodgkin's B lymphoma, multiple myeloma, non-small cell lung cancer). In thymus, CD40 is expressed in cortex, medulla and thymic stromal cells. When stimulated by inflammatory cytokines such as IL-1, IL-3, TNF-alpha, GM-CSF and IFN-gamma, the ability of these cells to express CD40 was significantly enhanced. When stimulated by IFN-gamma, the expression of CD40 was up-regulated most significantly and could stimulate the expression of CD40 in tumor cells.
CD40 (Fc tag)
Cat#Abt-P-408b
Expression host: HEK293
Molecular weight: 55-60 kD
Concentration: 1-2 mg/ml
Purity: > 90%
Preservation environment: 1 x PBS (pH 7.4)
Corresponding parameter set not found, please add it in property template of background
暂未实现,敬请期待
暂未实现,敬请期待
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