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What are the applications of TRIS (tromethamine) in medicine TRIS, also known as tromethamine, CAS number: 77-86-1, abbreviated as THAM abroad, appears as a buffer in biochemical experiments to adjust the pH of the system. In fact, in the field of medicine, tromethamine itself is used as a drug and an important pharmaceutical intermediate. It is used for the compounding of multiple drugs and can also be used as a pharmaceutical excipient. This article will describe the application of tromethamine in medicine.
Desheng talks about the development and utilization prospect of carbomer The use of carbomer in oral protein drug preparations is also of great significance to the oral absorption of protein drugs. According to reports, carbomer can complex Ca2+ and Zn2+, and these two ions are the coenzymes of Typsin and Carboxypeptise A, respectively. , Thus the activity of the enzyme is inhibited; and carbomer has a large number of amino groups, which releases protons in the intestinal tract to form local acidity and inhibit the activity of microbial proteases. Because carbomer can complex Ca2+, improve the permeability of cell membrane, thereby promoting drug absorption.
1 day ago
Luminescent materials combined with bioimaging technology help early diagnosis of liver injury Liver diseases such as hepatitis, liver cirrhosis, fatty liver, and acute liver failure are extremely harmful, and early diagnosis is beneficial to the prevention and treatment of such diseases. In common liver function test items, in vitro diagnostic reagent materials play an important role. In addition, molecular fluorescent probes are also indispensable research methods in modern life sciences and disease diagnosis. Recently, researchers from the Army Military Medical University and the People’s Hospital of Wuhan University have jointly developed a biodegradable luminescent material, and combined with fluorescence imaging technology to prepare a nanoprobe to achieve neutrophil-mediated acute Luminescence imaging of liver injury is of great significance for the diagnosis, prevention and treatment of liver injury.
2 days ago
Desheng takes you to understand chemiluminescence immunoassay technology Chemiluminescence, as its name implies, is the luminescence phenomenon produced by substances in the process of chemical reactions. In fact, this is the knowledge in high school physics. When a substance is in the process of a chemical reaction, its substance molecule absorbs chemical energy and transitions from one energy level to another energy level to release photons (that is, the substance molecule changes from the ground state under the action of energy). Become an excited state. After the energy is applied, the material molecules release light signals in the process of returning from the excited state to the ground state). In layman's terms, it's like setting off fireworks. After the firework is ignited, the substance inside burns. Under the action of a certain principle, a "firework ball" is ejected. Due to physical action, a large number of fireworks are released. We see that these fireworks released in the sky are like chemiluminescence phenomena. Photon".
3 days ago
How to do blood analysis after blood collection tube Before blood collection with a vacuum blood collection tube, various reagents such as separating gel, coagulant, heparin, and dipotassium EDTA will be added to deal with various blood tests, but this is only the first step in blood testing, which is a blood sample A pre-processing process. After the blood collection tube collects blood, how is the follow-up blood analysis done?
The difference between acridinium ester direct chemistry and alkaline phosphatase (AP) chemiluminescence Chemiluminescence immunoassay methods can be roughly divided into three categories according to their labels, direct chemiluminescence, enzymatic chemiluminescence, and electrochemiluminescence. Alkaline phosphatase (AP) chemiluminescence is a kind of enzymatic chemiluminescence, which is specially developed for the application of alkaline phosphatase (AP) enzyme-linked immunosorbent assay. It is recommended for enzyme-linked immunosorbent assay and western blotting. Method, Southern blotting or any other solid surface for staining application and detection of alkaline phosphatase-labeled nucleotide and protein probes.
Chemiluminescence series of acridine esters to be "shipped" Chemiluminescence analysis is a type of molecular luminescence spectroscopy. It means that when a substance undergoes a chemical reaction, due to the absorption of the chemical energy generated during the reaction, the reaction product molecule is excited to an excited state, and the excited molecule changes from the excited state. When returning to the ground state, it emits light of a certain wavelength, so chemiluminescence detection does not require other light sources, its background noise is small, and the detection sensitivity is high. It is extremely useful in the analysis of complex systems such as low-concentration test objects in biological samples. Big advantage.
Analysis of Common Components and Principles of Magnetic Bead Extraction Reagents The magnetic bead method of nucleic acid purification technology uses nano-scale magnetic beads. The surface of the magnetic beads is labeled with a functional group that can react with nucleic acid by adsorption. Magnetic Silica Particle means that the surface of magnetic beads is wrapped with a layer of silicon material to adsorb nucleic acids. Its purification principle is based on the purification method of glass milk. So what are the common ingredients in the reagents using magnetic bead extraction, and what is the principle? The editor of Desheng lists some common ingredients in turn, SDS (sodium dodecyl sulfate)-properties: