RNA SE T2 (ribonuclease T2) is an enzyme belonging to the RNase T2 family. It is abundantly expressed in temporal lobe and fetal brain. RNASET2 gene is a new member of extracellular ribonuclease Rh/T2/S-glycoprotein. It is a single copy gene, located in a region 6q27 related to human malignant tumors and chromosome rearrangement. The absence of RNASET2 is the cause of white matter cystic lesions without megaencephalopathy, which is a childhood onset syndrome of leukoencephalopathy. It can affect the development of neonatal microcephaly and neurological abnormalities, including psychomotor disorders, epileptic seizures and sensorineural hearing impairment. The brain shows multiple white matter lesions, anterior temporal subcortical cyst wall, abnormal myelin sheath development, and so on. Ventricular enlargement and intracranial calcification.
The RNASET2 provided by our company is a gene recombinant product expressed in mammalian cells with high purity, excellent immunogenicity and biological activity.
Expression host: HEK293 mammalian cells
Source: A DNA sequence encoding the extracellular domain of human RNA SET2 (NM_003730.4)
Preservation buffer: PBS (pH 7.4)
Molecular weight: 36-42 KDa (SDS-PAGE detection)
Purity: ≥ 95% (SDS-PAGE detection)
Preservation conditions: short-term preservation at 4 C or long-term preservation at - 20 C, avoiding repeated freezing and thawing as far as possible
Transportation Conditions: Low Temperature Ice Bag
Safety Tips: Not Used in Human Experiments
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