TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also known as Vstm3, Vsig9, WUCAM, is a newly discovered synergistic immunosuppressive molecule with molecular weight of 30-34 kD. It is expressed on T cells and NK cells. It has immunoglobulin-like domain, transmembrane region and immunoglobulin tyrosine inhibitory motif (ITIM), so it is named TIGIT. TIGIT is type I transmembrane protein and belongs to CD28 member of Ig superfamily. Human TIGIT has 244 amino acids, including 21 AA signal peptide, 120 AA extracellular domain (containing V immunoglobulin-like domain and two potential N-terminal glycosylation sites), 21 AA transmembrane domain, and 82 AA cytoplasmic region with ITIM motif.
TIGIT is a new inhibitory receptor shared by NK and T cells. It has a high affinity with PVR (CD155) which is highly expressed in tumor cells. It directly inhibits the killing effect of NK and T cells through ITIM region of TIGIT. The effect is similar to that of CTLA-4 on T cells.
Molecular weight: 18-23 kD
Concentration: 1-2 mg/ml
Purity: > 90%
Preservation environment: 1 x PBS (pH 7.4)
Storage conditions: 4 degree C short-term storage and - 20 degree C long-term storage. Avoid repeated freezing and thawing
Safety Tips: Not Used in Human Experiments