CTLA-4 his tag

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), also known as CD152, is a leukocyte differentiation antigen and a transmembrane receptor on T cells. CTLA-4 consists of 35aa signal peptide, 126aa extracellular domain, 21aa transmembrane domain and 41aa cytoplasmic domain. CTLA-4 shares B7 ligand with CD28, while CTLA-4 binds to B7 molecule to induce T cell nonresponsiveness and participate in negative regulation of immune response. Recombinant CTLA-4 Ig can effectively and specifically inhibit cellular and humoral immune responses in vivo and in vitro. It has significant therapeutic effects on transplant rejection and various autoimmune diseases with very low toxicity and side effects. It is considered as a promising new immunosuppressive drug at present.

(His tag)

Expression host: HEK293

Molecular weight: 22-27 kD

Concentration: 1-2 mg/ml

Purity: > 90%

Preservation environment: 1 x PBS (pH 7.4)

Storage conditions: 4 degree C short-term storage and - 20 degree C long-term storage. Avoid repeated freezing and thawing

Safety Tips: Not Used in Human Experiments