Chemiluminescence reagent acridinium ester detection items

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The emergence of chemiluminescence reagent acridinium esters has greatly improved the in vitro diagnostic detection technology. Its sensitivity is higher than the original radioimmunoassay, enzyme immunoassay, and fluorescence immunoassay. It enables many qualitative detection items to be quantitatively detected or It has advantages in early diagnosis of many diseases by making indicators that could not be detected become detectable.

Acridine ester chemiluminescence reagent

Chemiluminescence for thyroid function testing

As a chemiluminescent reagent, acridinium ester can directly label proteins, antibodies and other macromolecules, and can be used to detect thyroid hormone, thyrotropin, thyroglobulin, anti-thyroglobulin antibodies and other indicators. The off-sample fasting peripheral venous blood of the subject used for the luminescence detection of acridine esters was placed in a vacuum blood collection tube without anticoagulant separation gel, centrifuged at room temperature, and the separated serum was stored at -20°C for subsequent testing. Chemiluminescence detection can be used for the diagnosis of hyperthyroidism, hypothyroidism, and thyroid-related diseases and the monitoring of drug efficacy.

Chemiluminescence method to detect gonadal function

The detection of estradiol, testosterone, progesterone, human chorionic gonadotropin HCG and other indicators can also be detected by the chemiluminescence method of acridinium esters. The detection of these indicators can be used to diagnose infertility, pregnancy testing, sexual function, Problems such as precocious puberty in children.

Chemiluminescence method for detection of glucose metabolism

There are many detection methods for glucose metabolism, the most commonly used is enzyme-linked immunoassay, but the sensitivity of chemiluminescence is higher, and the detection of some very small indicators also requires acridinium esters, such as C-peptide, insulin, and anti-glutamine. Acid decarboxylase antibody, anti-human insulin antibody, etc.

Acridine ester tumor marker detection

The treatment of cancer is a major problem for humans. Early and early diagnosis is essential for treatment. There are dozens of existing tumor markers. The more mainstream method is to use acridinium ester chemiluminescence detection. Indicators include some carbohydrate antigens, alpha-fetoprotein, carcinoembryonic antigen, prostate specific antigen, protease and so on.

In addition to the above-mentioned test items, there are many test items applicable to acridinium esters, such as liver and kidney function, bone metabolism, immunoglobulin, cardiovascular and myocardial markers, and even some infectious diseases and viruses. Desheng is one of the earliest domestic manufacturers engaged in the R&D and production of chemiluminescence reagents. Currently, there are six models of acridinium esters available.