Hydroxyethylpiperazine ethanesulfonic acid HEPES—"Cosmetic Efficacy Booster"
HEPES is a widely used biological buffer. Its characteristic is that it can control the pH of the system for a long time without complexing with metal ions. Next, we will introduce the various uses of HEPES, especially in cosmetics. The specific role.
● Cosmetics: whitening products, repair products, anti-aging products, fruit acid products, etc.
● Other industries: cell culture fluid, organ preservation fluid, virus preservation fluid, low-temperature (frozen) preservation diluent and buffer solution of sperm for livestock breeding and reproduction, etc.
HEPES (Hydroxyethylpiperazine ethanesulfonic acid)
The specific role of HEPES in cosmetics
HEPES is weakly acidic, can gently destroy the desmosomes that connect between keratinocytes, promote the exfoliation of the stratum corneum, smooth and soften the skin, brighten the complexion, and promote whitening.
2 Excellent pH buffering capacity
● The pH buffer range is 6.8-8.2
● Will not combine with metal cations such as Mg2+ and Ca2+
● The pKa is 7.48 (25°C), which is very suitable for microorganism fermentation extracts to maintain activity
● Helps stabilize the activity of peptides, nucleic acids, and fermentation extracts
● Helps stabilize the pH of the product during the three-year shelf life
3 Promoting penetration
HEPES is a safe and efficient penetration enhancer for cosmetics, which can gently and quickly promote the absorption of nutrients in cosmetics with high penetration enhancement efficiency. This may be one of the reasons why this ingredient is added to many major brands of whitening, anti-aging, repair and other products.
4 Anti-inflammatory effect
Artificially induced skin edema in rats, 21μmol/L (about 5g/L) HEPES can produce anti-inflammatory effects.
Generally, the culture medium containing 20mmol/L (approximately 4.77g/L) HEPES can play a good buffering effect and is non-toxic to cells. 2% HEPES facial mask liquid, 12 people (2 of them with sensitive skin) used it twice a week for 1 month, none of which was irritating.
Formulation application recommendations
★ Suggested addition amount: 1.0%-5.0%
★ Water solubility: easily soluble in water, can be added directly after ≤45℃
★ Tip: It is ionic
★ Applicable dosage forms: liquid, facial mask, transparent system, essence, cream, etc.
HEPES applicable product types
✦ Whitening products
✦ Repair products
✦ Anti-aging products
✦ Peptide products
✦ Fermented extract products
✦ Neutral system
✦ Peeling keratin products
✦ Moisturizing products
Desheng’s HEPES products have reached long-term cooperative relations with many cosmetics companies. No matter what, good products can only be known after they are used. Desheng is an enterprise that emphasizes long-term development and requires the trust and support of our customers. . We recommend that you use our trial pack first when purchasing the product. Because we firmly believe that quality is the greatest sincerity to give back to customers.
HEPES, as a zwitterionic buffer, increases the osmotic pressure of the cell culture system by increasing the concentration of solution ions, maintaining normal cell morphology and function, and improving cell survival rate. Widely used in cell culture, especially under specific conditions such as tumor cell culture, it is crucial to maintain cell growth and function.