What role does tris-hydroxymethylaminomethane play in eye drops?

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Tris (tromethamine) is an important organic chemical raw material. In addition to the well-known component used as a buffer in biochemical experiments, Tris is also widely used in the medical field, such as Used in eye drops. However, as people pay more attention to safety, there are often questions like: What role does Tris play in eye drops and is it safe for users? Here, the editor of Desheng compiled relevant information

Generally speaking, Tris mainly plays two roles in eye drops:

1. Adjust the pH of the eye drops

 Eye drops are one of the most commonly used drug formulations for eye diseases. For many eye diseases, eye drops have a direct and rapid therapeutic effect. Due to the special anatomical and physiological characteristics of the eyes, corresponding requirements are put forward for ophthalmic preparations: the pH of normal tears is 7.2 to 7.4, and the range of pH tolerated by normal eyes is 5.0 to 9.0. The pH value of the eye drops will directly affect the eye irritation and the efficacy of the drug. When preparing eye drops, a buffer should be added to adjust the pH value of the solution so that it is roughly similar to the tear fluid to reduce the impact on the eyes. Stimulus. At the same time, adjusting the pH value also needs to take into account multiple factors such as drug solubility and stability. Tris (Tris) is a commonly used pH regulator in eye drops.

Desheng Tris  bulk packaging

2. As an intermediate of active ingredients

As an organic amine, Tris can form a water-soluble double salt with insoluble substances with acidic groups. The most common eye drops containing Tris are ketorolac tromethamine eye drops. Ketorolac is a non-steroidal anti-inflammatory drug for injection. Ketorolac tromethamine is soluble in water and stable in aqueous solution, with antipyretic, analgesic and anti-inflammatory effects. It reversibly inhibits cyclooxygenase and deoxygenase, thereby inhibiting the biosynthesis of prostaglandins, thereby reducing the response of painful nerves to endogenous inflammatory factors, inhibiting peripheral nerve sensitization, and achieving the purpose of advanced analgesia. Ketorolac tromethamine eye drops are often used for inflammation and pain after eye surgery. So, the question is, are eye drops containing Tris safe?

First, as a drug that can be used for acute metabolic acidosis and acute respiratory acidosis, Tris itself can be used for humans.

Secondly, when we talk about the toxicity of any substance, we must not deviate from the dose. As a buffer, there are not many additives, and there will be no safety hazards in normal use;

Third, animal experiments and clinical studies have shown that ketorolac tromethamine eye drops can significantly reduce corneal sensitivity, have strong analgesic and anti-inflammatory effects, and have no obvious adverse reactions and high safety.

In summary, eye drops containing Tris are safe. However, although most eye drops are not prescription drugs, in principle, there is no need for regular use of eye drops. If eye discomfort occurs, it is best to seek medical treatment in time. Only when the cause of the disease is identified can the appropriate drugs be selected to relieve the symptoms, achieve the best therapeutic effect, and avoid the harm caused by the wrong drug use. Tris produced by Desheng PH regulators are widely used in biological buffers, and the output and order quantity are large, and the delivery is very fast. Welcome to consult and purchase!