In the current era of continuous upgrading of biosensing analysis and in vitro diagnostic technology, precise glucose monitoring is a core requirement for clinical diagnosis and treatment, chronic disease management, and scientific research experiments. The performance of enzyme preparations directly determines the detection level of sensing equipment. Glucose dehydrogenase (GDH), with its unique catalytic properties and strong adaptability, has become the core functional component of implantable glucose sensors and dual analyte sensors, and is a key support for achieving efficient, stable, and accurate glucose detection.

glucose dehydrogenase

1、 Glucose Dehydrogenase (GDH): Core Signal Converter for Sensing Systems

The core of biosensing analysis is to convert glucose concentrations that cannot be directly read into quantifiable electrical signals. This process is driven by highly specific and active enzyme preparations, and glucose dehydrogenase (GDH) plays a crucial role in fulfilling this mission. It has strong substrate specificity and can accurately identify glucose molecules without interference from other impurities in the sample, ensuring accurate detection results from the source. It is the core raw material for various glucose sensors.

In a complete sensing system, glucose dehydrogenase (GDH) serves as the core carrier of the enzyme sensing layer, building a signal bridge between glucose and electrodes. Its activity, stability, and specificity are the three major indicators that directly determine the detection limit, linear range, and service life of the sensor. It is a key benchmark for measuring device quality and is suitable for various types of detection devices such as implantable and portable devices.

2、 Core function of glucose dehydrogenase (GDH): efficient conversion of electrochemical signals

The core value of glucose dehydrogenase (GDH) is the precise conversion of glucose concentration to electrochemical signals. It can specifically catalyze glucose dehydrogenation reaction, oxidize glucose to gluconolactone, and synchronously complete electron transfer, which is the core link of the detection process. Paired with electron mediators such as ruthenium and osmium complexes, glucose dehydrogenase (GDH) can efficiently conduct the electrons generated by the reaction to the electrode surface, generating a current signal linearly related to glucose concentration. After processing, it is converted into intuitive concentration data, making it the "biological core converter" of the sensor.

Compared with traditional enzyme preparations, glucose dehydrogenase (GDH) catalytic reaction is not affected by oxygen concentration interference, greatly improving detection stability. The catalytic process is mild and does not damage the sample, adapting to various harsh detection scenarios, with fast response and low error, which can meet the high-precision requirements of clinical and scientific research.

3、 Multivariate application of glucose dehydrogenase (GDH): adaptation for dual analyte synchronous monitoring

With the upgrading of detection demand, synchronous monitoring of dual analytes has become a new trend in the industry, and the adaptation advantages of glucose dehydrogenase (GDH) are further highlighted. In dual analyte sensors such as glucose+β - hydroxybutyric acid and glucose+ethanol, glucose dehydrogenase (GDH) serves as the exclusive enzyme for the glucose sensing layer and can perform its own duties with the second electrode specific enzyme, without cross signal interference, achieving synchronous, independent and accurate monitoring of the two substances, breaking the limitations of single detection.

Relying on stable performance, glucose dehydrogenase (GDH) can achieve standardized mass production applications, with a unified scheme for dosage and immobilization process, which can ensure consistent performance of sensor batches, improve production efficiency, and reduce enterprise research and development production costs. It is widely used in clinical chronic disease monitoring, scientific research multi index analysis and other scenarios.

4、 New Desheng Glucose Dehydrogenase (GDH) Helps Replace Domestic Products in the Industry

Currently, glucose dehydrogenase faces pain points such as high procurement costs, long supply cycles, and unstable supply, which constrain the development of the domestic biosensing industry. Hubei Xindesheng focuses on industry demand and independently develops and produces highly active, stable, and specific glucose dehydrogenase (GDH). The product's various indicators are benchmarked against imported standards. The company can provide customized enzyme preparation solutions, combined with professional technical support, to help customers optimize product performance and reduce costs.