Creatine kinase (CK) is a type of enzyme that plays a critical role in cellular energy metabolism, widely involved in the synthesis and breakdown of phosphocreatine, providing rapid and usable energy for cellular activity. According to its subunit composition, CK can be divided into three main isoenzymes: CK-MM, CK-MB, and CK-BB, each with its own characteristics in tissue distribution and clinical significance. CK-MM mainly exists in skeletal muscle, while CK-BB is mainly distributed in brain tissue, smooth muscle, and certain tumor cells. Although CK-MB does not account for a high proportion in the overall CK, it has become an important indicator for clinical evaluation of myocardial injury due to its high concentration in myocardial tissue.

CK-MB

The value of CK-MB in the diagnosis of acute myocardial infarction

CK-MB has a clear time advantage in the diagnostic process of acute myocardial infarction. Research has shown that serum CK-MB activity can be detected to increase approximately 4 hours after the occurrence of AMI; Peak within 16 to 24 hours; It usually returns to normal levels within 48 to 72 hours. This dynamic characteristic of rapid rise and rapid fall makes it not only useful for early identification of myocardial injury, but also for evaluating the scope of myocardial infarction and determining the probability of recurrent infarction.

The reliable performance of CK-MB in a wide temperature range

The recommended temperature for the use of creatine kinase MB isoenzyme (CK-MB) is 35-45 ℃, and it exhibits stability under conventional biochemical testing conditions; When the temperature exceeds 50 ℃, the enzyme activity rapidly decreases, which also helps to control the reaction process and improve detection accuracy. The product undergoes strict quality control, with small differences between batches, making it suitable for the development and production of myocardial injury detection kits, especially for automated analysis platforms that require high repeatability and stability.

Advantages of Hubei Xindesheng CK-MB products

Hubei Xindesheng Biotechnology Co., Ltd. focuses on the research and production of core materials for in vitro diagnostics. The company has launched creatine kinase MB isoenzyme (CK-MB) products, which use advanced recombinant expression and purification processes to ensure high purity and high specific activity. The optimal pH range for this product is 9-11, and it can maintain over 80% enzyme activity under a wide range of pH 4-11 conditions. It is adaptable to various buffer systems and has strong compatibility.

Compared to other biomarkers, CK-MB testing has lower cost and mature technology, especially suitable for primary healthcare institutions or scenarios that require rapid screening. Despite the higher sensitivity of high-sensitivity troponin (hs cTn) in recent years, CK-MB still maintains an irreplaceable position in clinical practice due to its good specificity, stable detection performance, and clear metabolic patterns.

Hubei Xindesheng: Reliable guarantee from raw materials to clinical practice

In the field of in vitro diagnostics, the accuracy of reagents largely depends on the performance of core enzyme raw materials. As a key component in myocardial injury detection, CK-MB's activity, stability, and specificity directly affect the reliability of the final detection results. Hubei Xindesheng always adheres to the equal importance of scientific research and development and quality control, establishes a sound production management system, and ensures that every batch of CK-MB products meets high standard requirements.

If you are looking for CK-MB products with high activity, wide pH adaptability, and batch stability, Hubei Xindesheng provides professional support for you. Contact us immediately to obtain technical information, activity testing reports, and free samples related to enzyme preparations, and jointly build a more accurate diagnosis solution for myocardial injury.