In the field of modern analytical detection technology, chemiluminescence immunoassay (CLIA) has been widely used in many fields such as life sciences, clinical diagnosis, environmental monitoring, food and pharmaceutical analysis, etc., thanks to its many advantages. With the continuous innovation of technology, it is making great strides towards high sensitivity, multi-component joint detection, and automated detection.

 

(Acridine salt NSP-SA-NHS)

 

Significant advantages of chemiluminescence immunoassay

 

1. High sensitivity and wide linear range

 

CLIA has high analytical sensitivity and can detect extremely low concentrations of target substances. In clinical diagnosis, CLIA can accurately capture the presence of some early disease markers, such as cancer markers and trace antibodies against infectious disease pathogens, providing strong evidence for early diagnosis of the disease. Its wide linear range also ensures good accuracy and reliability in sample detection at different concentration levels. When detecting cancer biomarkers, CLIA can accurately measure their concentration changes, whether in the early stages of low biomarker concentrations or in the stages of increased biomarker concentrations during progression, providing key data for the development and adjustment of clinical plans.

 

2. No scattered light and low reagent consumption

 

CLIA has no scattered light interference during the detection process, making the detection signal more accurate. Compared to other optical analysis methods, it avoids the influence of scattered light on the detection results, greatly improving the accuracy of detection. CLIA has lower reagent consumption, which not only reduces detection costs but also reduces waste generation. In large-scale clinical testing or environmental monitoring, the advantage of low reagent consumption is particularly evident, which can reduce testing costs and improve testing efficiency while ensuring testing quality.

 

The Development of Chemiluminescence Immunoassay

 

1. Continuous improvement of high sensitivity

 

With the continuous advancement of technology, various new markers and labeling methods continue to emerge, driving the continuous improvement of CLIA sensitivity. New types of nanomaterial markers, such as quantum dots and nanogold, can enhance luminescent signals and further improve detection sensitivity. By optimizing the labeling method, the markers are combined with immune substances to reduce losses and interference during the labeling process, thereby improving the accuracy and sensitivity of detection.

 

2. Development of Multi component Joint Detection

 

In order to meet the needs of clinical diagnosis and other fields for simultaneous detection of complex samples and multiple indicators, CLIA is developing towards the direction of multi-component joint detection. By designing and synthesizing markers with different luminescent properties, combined with advanced detection instruments and data analysis software, multiple target substances in the sample can be detected and analyzed simultaneously. In the diagnosis of infectious diseases, antibodies or antigens against multiple pathogens can be detected simultaneously, improving the efficiency and accuracy of diagnosis.

 

Promotion of Automated Testing

 

Automated detection is an important trend in the development of CLIA. Traditional immune analysis requires manual mixing of immune substances, which not only reduces reaction efficiency and consumes a lot of time, but also easily introduces human errors. The application of Flow Injection Analysis (FIA) technology has changed this situation. FIA can automate analysis, reducing errors caused by manual operations and greatly shortening reaction time. By utilizing easily controllable electric fields to accelerate the mass transfer rate of immune substances, or using commonly used methods such as electromagnetic stirring, analysis time can also be reduced and the automation level of CLIA can be significantly improved. With the continuous development of technology, various fully automatic immune luminescence instruments with different functions have been continuously developed and widely used in clinical testing, improving detection efficiency and quality.

 

The Current Status of Automated Chemiluminescence Immunoassay

 

1. The gap between foreign dominance and domestic production

 

At present, the market for automated chemiluminescence immunoassay analyzers is mainly dominated by foreign companies. With advanced technology, mature processes, and rich market experience, foreign companies have significant advantages in the research and production of automated instruments. However, there is still a gap between domestically produced chemiluminescence immunoassay analyzers and imported products, and further improvement is needed in terms of instrument accuracy, stability, detection speed, and multi-component joint detection capability. There is still a lot of room for improvement in replacing imported products.

 

(Luminescent reagent raw material isoluminol)

 

2. Market growth and domestic opportunities

 

With the increasing popularity of chemiluminescence immunoassay in clinical practice in China, the market size continues to grow. This provides a rare opportunity for the development of domestically produced automation instruments. Domestic enterprises are continuously increasing their R&D investment, actively introducing advanced technologies and talents, and striving to enhance their own R&D and production capabilities. Through cooperation with universities and research institutions, we carry out joint research and development of industry, academia, and research, continuously overcome technical difficulties, and improve product quality and performance. With the passage of time and the accumulation of technology, the gap between domestic automation instruments and foreign products will gradually narrow, and it is expected to occupy a larger share in future market competition.

 

Hubei Xindesheng plays an important role in the development process of chemiluminescence immunoassay technology. Xindesheng focuses on the research and production of in vitro diagnostic reagent raw materials, providing reliable raw material support for chemiluminescence immunoassay. In terms of luminescent reagent raw materials, products such as acridine esters produced by Xindesheng have the characteristics of high purity, high luminescence efficiency, and strong stability, which can provide clear and reliable luminescent signals for CLIA, improving the sensitivity and accuracy of rapid detection. If you have any purchasing needs, please feel free to contact us at any time!