Reasons and coping strategies for the phenomenon of "wire drawing" in serum separation gel at room temperature
Release time:
2025-03-13
Serum separation gel is an indispensable additive for blood collection tubes. However, when adding serum separation gel at room temperature, experimenters sometimes encounter a headache problem - wire drawing phenomenon. This phenomenon not only affects the smoothness of experimental operations, but may also cause certain interference to the experimental results. So, what is the reason for the wire drawing phenomenon of serum separation gel when added at room temperature? How can we effectively solve this problem?
serum separation gel
Let's first understand the basic characteristics of serum separation gel. Serum separation gel is a colloidal substance with specific viscosity and fluidity, and its performance is influenced by various factors. At room temperature, the viscosity of serum separation gel is usually high, which makes it prone to wire drawing when subjected to external forces. This is because high viscosity liquids generate significant internal friction when flowing, making it difficult for the liquid to break and form slender filaments. In addition, the operation technique and speed can also have an impact on the wire drawing phenomenon. When quickly adding serum separation gel, due to insufficient shear force, the gel is not easy to spread quickly and is prone to forming wire drawing. Uneven movements or uneven force may also lead to the accumulation or stringing of serum separation gel.
So, how to effectively solve the wire drawing phenomenon when serum separation gel is added at room temperature? There are two main methods here: increasing the glue temperature appropriately and shaking the wire to break it.
Properly increasing the glue temperature is a simple and effective method. Due to the decrease in viscosity of serum separation gel with increasing temperature, heating can reduce its viscosity, improve fluidity, and thus reduce wire drawing phenomenon. Experimenters can preheat the serum separation gel in a 37 ℃ water bath for a few minutes before use to moderately reduce its viscosity. However, please note that the heating temperature should not be too high to avoid damaging the performance of the serum separation gel or causing safety hazards.
Another method is to use vibration to break the wire. During the process of adding serum separation gel, slight vibration can be used to interfere with the arrangement and interaction of colloidal molecules, thereby avoiding the occurrence of wire drawing phenomenon. This method requires experimenters to have certain operational skills and experience to ensure that the vibration amplitude and frequency are moderate and will not have a negative impact on the experimental results.
Product packaging
In summary, the phenomenon of wire drawing when serum separation gel is added at room temperature is a common problem, but as long as we have a deep understanding of its causes and take effective measures, we can successfully solve this problem. Desheng New Materials suggests that increasing the glue temperature appropriately and using vibration to break the wire are two simple and effective methods that can help us improve the smoothness and accuracy of experimental operations, providing strong support for subsequent experimental research.
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