Tim-3 his tag

T cell immunoglobulin and mucin domain-3 (Tim-3), also known as HAVCR2, is a member of the TIM family of immunoregulatory molecules and a type I transmembrane glycoprotein with a molecular weight of 60 kD. Mature human Tim-3 consists of 181aa extracellular domain, 21aa transmembrane domain and 78aa cytoplasmic domain. Tim-3 is one of the important members of T cell immunoglobulin family. It is a key molecule that regulates CD4 + CD25 + regulatory T (TR) cells expressed by activated Th1 cells. Th1 cells express full-length membrane-type Tim3 (flTim3) and soluble Tim3 (sTim3) through RNA splicing. Tim-3 is mainly expressed in mature Th1 cells, which can down-regulate Th1 cell immune response by binding with its ligand galactosin-9.

Tim3-his and Tim3-Fc expressed in mammalian cells are of high purity and activity.

Tim 3 (His tag)

Expression host: HEK293

Molecular weight: 28-52 kD

Concentration: 1-2 mg/ml

Purity: > 90%

Preservation environment: 1 x PBS (pH 7.4)

Storage conditions: 4 degree C short-term storage and - 20 degree C long-term storage. Avoid repeated freezing and thawing

Safety Tips: Not Used in Human Experiments