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Add：C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
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- Usage Introduction
- Product advantages
- Commodity name: Her2 , ErbB2 his tag
- Commodity ID: 1080800595733532672
- 储存条件: It can be stored for one year at 4 ℃ and for two years at -20 ℃
Human epidermal growth factor receptor 2 (Her2, ErbB2)
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, is a type I membrane glycoprotein and belongs to the epidermal growth factor receptor family. HER2 itself has no ligand binding domain and therefore cannot bind growth factors, but it binds tightly with other ligand binding epidermal growth factor receptor family members to form a heterodimer, which stabilizes ligand binding and enhances kinase-mediated downstream signals Pathways, such as mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
HER2 is highly invasive in breast cancer. Nearly 30% of breast cancers show a significant increase in the HER2 gene or overexpression of the protein produced by this gene. Overexpression of receptors in breast cancer is closely related to disease recurrence and poor prognosis. HER2 plays an important role in the regulation of development, cancer, neuromuscular signaling and cell growth and differentiation.
The HER2 produced by our company is a recombinant protein derived from mammalian cells, with high purity, good immunogenicity and high biological activity.
Expression host: HEK293 mammalian cells
Source: A DNA sequence encoding the extracellular region of ErbB2 (NM_004448.3)
Storage buffer: PBS (pH7.4)
Molecular weight: around 95-115 KDa (SDS-PAGE detection)
Purity: ≥95% (SDS-PAGE detection)
Storage conditions: Short-term storage at 4℃ or long-term storage at -20℃, try to avoid repeated freezing and thawing.
Transportation conditions: Low temperature ice pack
Safety Tips: Not for human experiment