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Add：C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
E-mail：18062302654@163.com
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- Description
- Usage Introduction
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Regulating immune response
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(Integrin-associated protein, IAP)
CD47, also known as integrin-associated protein (IAP), or OA3, is an important member of the immunoglobulin (Ig) superfamily and is widely expressed in cells of different tissues. The chemical property of CD47 is a membrane glycoprotein of 40-60 kD, consisting of an extracellular region of 123aa, five transmembrane fragments with highly hydrophobic extension, and a short selective splicing of carboxyl-terminal cytoplasmic tail region of 34aa. The role of the CD47 molecule in the body's multiple regulatory functions is mainly based on the interaction with signal regulatory proteins, thrombospondin, and integrin, involved in the transmembrane migration of neutrophil monocytes and T cells and phagocytosis Regulation; promote the chemotaxis and spread of platelets, tumor cells and smooth muscle cells; inhibit the release of IL-12 in monocytes, while inhibiting the promotion of exogenous IL-12 on the evolution of Th1 cells; in addition, it can also induce lymphocyte apoptosis Death and other physiological processes. As an important immune factor, CD47 plays a key role in the body's immune regulation.
The CD47-his and CD47-Fc expressed by the mammalian cells of the company have high purity and good activity.
CD47 (Fc tag)
Expression host HEK293
Molecular weight: 52-66kD
Concentration: 1-2mg / ml
Purity:> 90%
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing
Safety Tips: Not for human experiment
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Address: C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
Fax：0711-3704 589
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