Dispersion and sterilization method of carbomer gel
Because of its very good thickening and suspending properties, carbomer is usually made into gel and used in various daily chemical products, biochemical experiments and pharmaceutical excipients. In high-end skin care products or pharmaceutical excipients, carbomer gel is required to be sterile, and it cannot promote bacterial growth or sterilization, so it needs to be sterilized.
Carbomer gel sterilization method
Carbomer Irradiation Sterilization
Sterilization by Co60 irradiation is a common sterilization method. However, because the carbomer is irradiated, the structure will change and the viscosity will decrease to varying degrees. Before irradiating the carbomer solution for sterilization, add A proper amount of glycerin can prevent the structure of carbomer from being destroyed, thus greatly improving the wide application of carbomer.
Carbomer Moist Heat Sterilization
Carbomer is treated by moist heat sterilization, that is, carbomer powder is usually made into carbomer solution and then sterilized. However, carbomer powder is easy to form a high-viscosity gel in water, and when it is scattered in vigorously stirred water, it hydrates slowly and tends to form a lumpy shape. When it is sterilized by moist heat, it cannot achieve good results due to uneven heat dispersion. Sterilization effect. In addition, after turning into a gel, the carbomer solution has a high viscosity and poor fluidity, and it cannot be sterilized by microporous membrane filtration or sterilized by Co 60 irradiation.
Carbomer alkali metal salt sterilization
Adding alkali metal salt and/or alkaline earth metal salt to the carbomer solution can prepare a carbomer solution with qualified microorganisms and good fluidity, and control the environmental microbial load during the preparation process, which is widely used in the preparation of sterile preparations . The alkali metal salt is an inorganic salt of an alkali metal, such as one or more of alkali metal nitrate, alkali metal sulfate and alkali metal chloride. The available options are sodium nitrate, sodium sulfate, sodium chloride, potassium nitrate, Potassium sulfate, potassium chloride, etc.; alkaline earth metal salts are selected from one or more of magnesium nitrate, magnesium chloride, calcium nitrate, calcium chloride, barium nitrate and barium chloride. First, filter the alkali metal salt solution through a 0.20-0.25μm filter element to effectively remove pathogenic microorganisms. Add carbomer to dissolve it and sterilize it at 100-130 degrees for 15=60 minutes.
The above-mentioned different carbomer sterilization methods have their own characteristics, and the sterilization method can be selected according to the different uses of carbomer. Desheng has rich experience in the synthesis and production of acrylic polymers, and can provide high-transparency and high-quality carbomer raw materials.
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