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Related protein research
Signal regulatory protein α (SIRPα, Signal regulatory protein α) is a regulatory glycosylated membrane protein from the SIRP family, which is mainly expressed in bone marrow cells, stem cells, or nerve cells.
Signal conditioning protein α (SIRPα) is the most important member of the SIRP family. On the one hand, SIRPα can be activated and phosphorylated by various mitogens, and binds to SHP-1 and SHP-2 through its ITIM domain to transmit inhibitory signals. On the other hand, SIRPα can also inhibit the activation of downstream pathways by interacting with CD47 ligands, transmitting negative signals. SIRPα plays an important role in the regulation of innate immunity. In macrophages, LPS can induce the down-regulation of SIRPα expression through transcriptional suppression and protein degradation pathways. SIRPα inhibits the activation of MAPK, IKKs, NF-κB, and IRF3 by shielding SHP-2. , Reduce the release of inflammatory factors and IFNβ. Studies have shown that SIRPα in dendritic cells (Dc) can also negatively regulate the function of DC and T cells by binding to CD47 on the surface of T cells. On the one hand, it inhibits the expression of IL-12R by T cells and makes adult CD4 + and CD8 + T cell reactivity to IL-12 is reduced: on the other hand, it inhibits the phenotype and functional maturation of immature DCs and inhibits the release of their cytokines. A
SIRPα (Fc tag)
Expression host: HEK293
Molecular weight: 75-95 kD
Concentration: 1-2mg / ml
Purity:> 90%
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment
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