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- Description
- Usage Introduction
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Inducing T cell proliferation, differentiation, and cytokine production
Human 4-1BB(Receptor induced by lymphocyte activation, ILA)
4-1BB is called receptor induced by lymphocyte activation (ILA), also known as CD137, and is also known as a member of the tumor necrosis factor receptor superfamily 9, TNFRSF9. Costimulatory molecule 4-1 BB and its ligands are members of the tumor necrosis factor receptor superfamily. 4-1BB is a type I transmembrane protein. The mature 4-1BB protein contains 256 amino acids and has a relative molecular mass of 30 kD. It is mainly composed of 163aa extracellular domain, 27aa transmembrane domain and 42aa cytoplasmic domain. The ligand of 4-1BB, 4-1BBL, is a type II transmembrane glycoprotein, mainly expressed in professional antigen-presenting cells, such as B cells, macrophages and dendritic cells (DC). The human 4-1BBL gene encodes a protein consisting of 254 amino acids. There are two types, membrane-bound and soluble, which are biologically active.
The interaction between 4-1BB and its ligand 4-1 BBL can provide a second signal independent of CD28 signal for T cell activation, induce T cell proliferation, differentiation and cytokine production, participate in autoimmune diseases and tumor , Viral infection, transplant rejection and inflammation of the immune regulation process. Its regulatory function and regulatory mechanism have now become a hot spot in immunology research.
4-1BB-his and 4-1BB-Fc expressed by the mammalian cells of the company have high purity and good activity.
4-1BB (Fc tag)
Expression host: HEK293
Molecular weight: 52-65 kD
Concentration: 1-2mg / ml
Purity:> 90%
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment
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Address: C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
Fax：0711-3704 589
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