Cell membrane glycoprotein (CD105) is a type I transmembrane glycoprotein belonging to zona pellucida (ZP) protein family with molecular weight of about 90 kDa. Membrane glycoproteins and beta-glycans (TbetRIII) are type III receptors of transforming growth factor beta superfamily ligands, which are identical to 71% amino acids in transmembrane (TM) and cytoplasmic domains. Membrane glycoprotein was highly expressed in proliferating endothelial cells, chondrocytes and full-term placental syncytiotrophoblast cells. In addition, hematopoietic cells, mesenchymal and neural crest stem cells, activated monocytes, lymphoid and myeloid leukemia cells were also expressed in a small amount.
As an auxiliary receptor of TGF-beta superfamily ligand, cell membrane glycoprotein does not directly bind to TGF-beta 1 and TGF-beta 3, but activates its downstream signaling pathway by associating with type II receptor (TbetR II) of TGF-beta. In addition, ALK-1 is also a membrane glycoprotein threonine phosphorylated receptor kinase in human umbilical vein endothelial cells. Mutations in either of these two genes will lead to autosomal dominant hereditary vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Cell membrane glycoproteins have been recognized as a powerful biomarker of neovascularization and are associated with a variety of solid tumors.
The cell membrane glycoprotein provided by our company is a gene recombinant protein derived from mammalian cells. It has the characteristics of high purity, good immunogenicity and high biological activity.
Expression host: HEK293 mammalian cells
Source: A DNA sequence encoding human CD105 (NM_001114753.2) extracellular domain (Glu26-Gly586)
Preservation buffer: PBS (pH 7.4)
Molecular weight: 80-90 KDa (SDS-PAGE detection)
Purity: > 95% (SDS-PAGE test)
Preservation conditions: short-term preservation at 4 C or long-term preservation at - 20 C, avoiding repeated freezing and thawing as far as possible
Transportation Conditions: Low Temperature Ice Bag
Safety Tips: Not Used in Human Experiments