Classification:
Kit materials and others
Phone
Add：C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
E-mail：18062302654@163.com
Scan
Follow WeChat mini program
Real time understanding of company dynamics
- Description
- Usage Introduction
-
Surface expression of various histiocyte
Human CD40 (TNFRSF5)
CD40, also known as TNFRSF5, is a member of the tumor necrosis factor receptor superfamily (TNFR-SF) and is a type I transmembrane glycoprotein with a molecular mass of 45-50kD. It contains 173 AA extracellular regions, transmembrane regions, and 62 AA cytoplasmic regions. Like other members of the TNFR family, the extracellular segment of the CD40 molecule has four serine-rich amino acid repeats (CRDs1-CRDs4), and the regions that bind to CD40L are mainly CRD2 and CRD3. CD40 is mainly expressed in B cells, thymic epithelial cells, activated monocytes / macrophages, dendritic cells, hematopoietic cells, epithelial cells, endothelial cells and some tumors (such as ovarian cancer, nasopharyngeal cancer, bladder cancer, liver cancer, Adenocarcinoma, Hodgkin's disease, chronic lymphocytic leukemia, non-Hodgkin's B lymphoma, multiple myeloma, non-small cell lung cancer) cells, etc. In the thymus, CD40 is expressed on the cortex, medullary epithelium, and thymic stromal cells. These cells continue to express CD40 at low levels in a non-disease state, and when stimulated by inflammatory cytokines such as IL-1, IL-3, TNF-α, GM-CSF, IFN-γ, etc., the ability of these cells to express CD40 is significantly enhanced , And when stimulated with IFN-γ, the expression of CD40 was most up-regulated, and it could stimulate tumor cells to express CD40.
The CD40-his and CD40-Fc expressed by the mammalian cells of our company have high purity and good activity.
CD40 (His tag)
Expression host: HEK293
Molecular weight: 28-34 kD
Concentration: 1-2mg / ml
Purity:> 90%
Storage environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage at -20℃. Avoid repeated freezing and thawing
Safety Tips: Not for human experiment
Message Enquiry
Contact details
Contact number
Address: C8, Guanggu United Science and Technology City, Ezhou City, Hubei Province
Fax：0711-3704 589
Follow us