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How does α-glucosidase reduce blood sugar and what are its advantages?

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How does α-glucosidase reduce blood sugar and what are its advantages?

Classification:
News
Author:
2020/10/28 16:00

High blood sugar after meals seems to be a common problem among Chinese diabetic patients. Often the fasting blood sugar has been well controlled, and the blood sugar rises again after a meal, which is really difficult. Alpha-glucosidase inhibitors can solve this problem well. Alpha-glucosidase inhibitors are a kind of oral hypoglycemic drugs that delay the absorption of intestinal carbohydrates to treat diabetes. It is a relatively mature medicine for treating diabetes and has been widely used in clinics.

Alpha-glucosidase hypoglycemic mechanism:

Alpha-glucosidase plays an important role in the absorption of food, and food must be combined with this enzyme to be digested and absorbed. Alpha-glucosidase inhibitor drugs slow down the absorption of glucose in the intestines and reduce postprandial hyperglycemia by inhibiting the alpha-glucosidase on the intestinal mucosa. Since it does not stimulate insulin and does not cause hypoglycemia by itself, it helps reduce blood sugar fluctuations and keep blood sugar stable throughout the day.

Advantages of α-glucosidase inhibitors:

Alpha-glucosidase inhibitors can not only reduce postprandial hyperglycemia, but also will not cause hypoglycemia. This unique "peak and trough" effect can help reduce the risk of cardiovascular disease in diabetic patients. Alpha-glucosidase inhibitors can effectively reduce postprandial hyperglycemia through its unique mechanism, and have the following benefits.

1. Reduce blood sugar fluctuations. Significant blood sugar fluctuations cause serious damage to large blood vessels

Alpha-glucosidase inhibitors can not only reduce postprandial hyperglycemia, but also will not cause hypoglycemia, avoiding blood sugar fluctuations. This unique "peak and valley" effect can help reduce the incidence of cardiovascular disease in diabetic patients. risk.

2. Significantly reduce the incidence of impaired glucose tolerance

Risk of Type 2 Diabetes Elevated postprandial blood glucose is the main sign of impaired glucose tolerance stage. Postprandial hyperglycemia can aggravate insulin resistance and insulin secretion defects. When the pancreatic β-cell function is only about 50%, fasting blood glucose will increase. , The impaired glucose tolerance develops type 2 diabetes. Therefore, controlling postprandial hyperglycemia is an important means to prevent impaired glucose tolerance from developing type 2 diabetes.

3. Significantly reduce the incidence of cardiovascular events in diabetic patients

A large number of epidemiological studies and clinical trials have confirmed that postprandial hyperglycemia is a high risk factor for cardiovascular complications and death. Therefore, controlling postprandial hyperglycemia can significantly reduce the risk of cardiovascular complications and death in diabetic patients. Studies have shown that α-glucosidase inhibitors significantly reduce the incidence of cardiovascular events by 35%. Among them, the reduction of myocardial infarction is the most significant, and other cardiovascular events also tend to decrease.

4. Improve insulin resistance

Alpha-glucosidase inhibitor does not reduce blood sugar by stimulating insulin secretion. It can reduce postprandial blood sugar while reducing postprandial insulin levels, indicating that it can increase insulin sensitivity.

Desheng produces a variety of enzyme preparation products. The enzyme preparation products provided are mainly used as test materials for kits. In addition to α-glucosidase, there are glucose dehydrogenase and glucose oxidase, cholesterol esterase, cholesterol oxidase, and purine nucleosides. Phosphorylase, lactate dehydrogenase, etc. Desheng has been continuously developing and researching advanced biochemical reagents based on the needs of the medical laboratory field to meet the needs of the global medical laboratory technology development and strive for the cause of human health.