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Antibacterial antibiotics in Virus Transport Media
The Virus Transport Media is a solution medium used for virus sampling, transportation, preservation, and detection. It is added to the virus sampling tube and has two types: inactivated and activated. Among them, activated preservation solution needs to add antibacterial antibiotics, including antibacterial antibiotics and antifungal antibiotics.
Since the activated Virus Transport Media needs to preserve the nucleic acid of the virus and the epitope on the protein membrane, it needs to retain the complete virus structure to extend the survival time of the virus in vitro, so it is necessary to add antibiotics for bacteria and fungi to prevent the growth of bacteria from causing the virus interference. Bacterial antibiotics are usually gentamicin. Here we mainly introduce several antifungal antibiotics.
Antibiotic-containing Virus Transport Media
1. Amphotericin b: A polyene spectrum antibiotic that is isolated from the culture broth of Streptomyces in the 1950s to resist deep fungal infections. The pH is stable at 4-10, and salts can be formed in neutral or acidic media, causing a decrease in antibacterial activity. It can selectively combine with ergosterol on the fungal cytoplasmic membrane to form micropores or channels in the membrane, thereby changing the permeability of the cytoplasmic membrane, leading to sodium ions, nucleotides, amino acids, etc. in the fungal cell Material leakage, normal metabolism is disrupted and play an antibacterial effect. When used for intravenous injection, there are many adverse reactions, and there are many contraindications, it is best to use alone.
2. Nystatin is a polyene antibiotic with a conjugated polyene macrolide structure, which is similar in structure to amphotericin (lushanmycin). It can inhibit the activity of fungi and dermatophytes without inhibiting bacteria. effect.
3. Griseofulvin: can inhibit fungal mitosis, break the mitotic spindle structure, and terminate metaphase cell division. This product is deposited in the keratin precursor cells of the skin and hair, which can promote the keratin to resist the invasion of fungi; when the infected keratin falls off, it replaces it with healthy tissue. It is effective for skin fungal infections caused by Epidermophyton, Microsporum and Trichophyton. It is not effective for other fungal infections including Candida and bacteria.
In addition, ketoconazole, terbinafine, undecylenic acid, salicylic acid and other drugs also have antifungal effects. Desheng's non-inactivated virus preservation solution contains two types of antibacterial and antifungal antibiotics, so the virus sampling tube set made is strictly sterile.