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How to extract high-quality heparin sodium from crude heparin sodium
The application range of heparin sodium is very wide. Low-molecular-weight heparin sodium belongs to injection-grade heparin sodium, which can prevent thrombosis and treat angina pectoris. It is mainly used for the prevention and treatment of thromboembolic diseases, and is especially suitable for people who need rapid anticoagulation. Heparin sodium can also be added to cosmetics such as nutrient creams, eye creams, anti-acne products and hair growth agents; it has a good health and maintenance effect on the skin, and can also be used as an additive in blood collection tubes to prevent blood collection. After the blood is rapidly coagulated in vitro, the heparin sodium produced by Desheng is mainly used in blood collection tube anticoagulant.
Heparin sodium is based on the titer. The heparin sodium produced by Desheng is between 150-180IU/mg. Heparin sodium is divided into crude and refined products. The crude heparin sodium used in general cosmetics is crude heparin sodium, while the injection heparin sodium has a low potency. High, but there will be no magazines. The blood collection tube additives are also high-quality heparin sodium. Crude heparin sodium is generally extracted from pig small intestine, and high-quality heparin sodium is extracted from crude heparin sodium. Here is a kind of high-quality heparin sodium. Extraction method.
Weigh 0. 4 g crude heparin sodium in a three-necked flask, add a certain concentration of sodium chloride solution for salt hydrolysis; heat in a water bath at 50 ℃, and turn on the magnetic stirrer for stirring. When the heparin sodium is completely dissolved, adjust the pH to with sodium hydroxide solution 8. 0, then add a certain amount of 30% hydrogen peroxide to oxidize, keep it at 20 ℃ for oxidation for several hours. 6. Suction filtration, and adjust the pH of the filtrate to 6 with hydrochloric acid or sodium hydroxide. 5. Add 1 times the volume of the filtrate with 95% ethanol, and perform precipitation at room temperature. Take the precipitate and vacuum dry at 50 ℃ for more than 3 hours to obtain heparin sodium. Some studies have pointed out that the best conditions for the purification process of heparin sodium are: sodium chloride concentration 2%, oxidant dosage volume fraction 3%, oxidation time 12 h.
The application range of heparin sodium is so wide, but the heparin sodium produced by Desheng cannot be used as injection heparin sodium. Instead, it can be used as an additive for blood collection tubes to play the role of blood anticoagulation. The specifications are 10g/bottle, 50g/bottle, or according to customers If you need to provide sub-packages, many daily biochemical tests need to use blood anticoagulants. If you have any needs in this regard, welcome to inquire. Desheng professional customer service will serve you wholeheartedly.